Liquid chromatography of basic solutes on silica gel and aluminum oxide.

Chromatography of Lipids on Commercial Silica Gel Loaded Filter Paper.

New silica gel-based monolithic column for nano-liquid chromatography, used in the HILIC mode.

This paper describes the synthesis and chromatographic and morphologic characterization of two monolithic silica nano-columns (50 µm i.d.) prepared by sol-gel processes, using hydrophilic interaction (HILIC) mode separations to evaluate their performance. Two types of monoliths were prepared by varying the precursors (tetraethoxysilane or a tetraethoxysilane-methyltrimethoxysilane mixture) and ...

Simultaneous determination of lidocaine and its principal metabolites by liquid chromatography on silica gel, with aqueous eluent.

We describe the simultaneous determination of lidocaine and its pharmacologically active metabolites, monoethylglycinexylidide and glycinexylidide, in plasma by "high-performance" liquid-chromatography. By use of a bare ( unbonded ) silica gel with aqueous eluents, separations of organic amines such as lidocaine and its metabolites, which are very difficult and have a poor peak symmetry on bond...

Liquid-gel chromatography on lipophilic-hydrophobic Sephadex derivatives.

Hydrophobic long-chain alkyl ethers of Sephadex have been synthesized and tested for use in liquid chromatography. With columns prepared in such polar solvents as methanol, reversed-phase systems are obtained where compounds separate in order of decreasing polarity. In such non-polar solvents as heptane, straight-phase systems are formed, and separations occur in order of increasing polarity. T...

Computational chemical analysis of the retention of acidic drugs on a pentyl-bonded silica gel in reversed-phase liquid chromatography.

A fast method to obtain a quantitative structure-retention relationship is required in chromatography for the rapid optimization of chromatographic separation conditions. Chromatographic data of acidic drugs are analyzed by a computational chemical method to simulate chromatographic simulation. The direct interaction between a model phase and a drug is calculated as an energy value using the mo...